The Importance of ACTN3 R577X Polymorphism in Athletic Performance and Modeling of R577X Mutant Type and Wild Type ACTN3 Protein by Bioinformatics Analysis
نویسندگان
چکیده
In studies conducted on the relationship between ACTN3 R577X polymorphism and athletic performance, it is known that performance polygenic, but most sensitive provided by gene. Considering results, conformational difference much less (
منابع مشابه
The ACTN3 R577X polymorphism in East and West African athletes.
PURPOSE To determine the frequency of the ACTN3 R577X polymorphism (functional R allele and nonfunctional X allele) in a variety of African populations and to examine its influence on the success of elite East African endurance runners and West African sprinters. METHODS The R577X polymorphism was genotyped in 198 Ethiopian controls and 76 elite Ethiopian endurance athletes, 158 Kenyan contro...
متن کاملACTN3 (R577X) genotype is associated with fiber type distribution.
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism in the ACTN3 gene results in a premature stop codon and alpha-actinin-3 deficiency in XX homozygotes. Associations between the R577X polymorphism and the muscle-power performance of elite athletes have been described earlier. About 45% of the fiber type proportions are dete...
متن کاملACTN3 R577X Polymorphism and Neuromuscular Response to Resistance Training.
The R577X polymorphism at the ACTN3 gene has been associated with muscle strength, hypertrophy and athletic status. The X allele, which is associated with the absence of ACTN3 protein is supposed to impair performance of high force/velocity muscle contractions. The purpose of the present study was to investigate the association of the R577X polymorphism with the muscle response to resistance tr...
متن کاملThe ACTN3 R577X variant in sprint and strength performance
PURPOSE The aim of this study is to examine the association between the distribution of ACTN3 genotypes and alleles in power, speed, and strength-oriented athletics. METHODS ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854). RESULTS Genetic associations were evaluated by...
متن کاملNo association between ACTN3 R577X polymorphism and elite judo athletic status.
The authors compared ACTN3 R577X genotype and allele frequencies in the majority of all-time-best Spanish judo male athletes (n = 108) and 343 ethnically matched nonathletic men. No between-groups differences were found in allele (P = .077) or genotype distributions (P = .178). Thus, the R577X polymorphism was not significantly associated with the status of being an elite judo athlete, at least...
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ژورنال
عنوان ژورنال: Cumhuriyet Üniversitesi sa?l?k bilimleri enstitüsü dergisi
سال: 2021
ISSN: ['2587-0874']
DOI: https://doi.org/10.51754/cusbed.880707